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http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum
Am going to preface this before copying it as I think the word "analogue" used to describe Humulin N is confusing.
An analog or analogue insulin would be an insulin which doesn't exist in nature. Human insulin is an exact copy of the insulin a normal human body produces. Insulins Novolog, Humalog, Apidra, Lantus and Levemir never existed until science created them by altering human insulin to produce either more rapid or slower absorption.
Describing it as r-DNA or GE (Genetically Engineered) insulin would seem to be more apt; Humulin N has a LOT more in common with Novolin N and ReliOn Novolin N as well as the non North American brand names for isophane insulin than it does the analogs.
With the hope of avoiding confusion, I'll be omitting that word from this copy of the abstract; the link is above.
An investigation of the action of Neutral Protamine Hagedorn human insulin in dogs with naturally occurring diabetes mellitus.
Department of Clinical Studies, Matthew J. Ryan Veterinary Hospital, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA, USA.
Journal of Veterinary Internal Medicine 2009
BACKGROUND: Neutral Protamine Hagedorn human insulin (Humulin N) is commonly used for treatment of canine diabetes mellitus (DM). However, blood glucose and serum insulin concentrations in Humulin N-treated dogs with naturally occurring DM have not been reported.
OBJECTIVE: To investigate blood glucose and serum insulin concentrations in the clinical setting of client-owned Humulin N-treated dogs with naturally occurring, well-regulated DM.
ANIMALS: Ten client-owned dogs with naturally occurring, well-regulated DM.
METHODS: In this clinical study, blood glucose and serum insulin concentrations were measured when dogs received food and insulin (T(0)), at approximately every half hour for the next 2 hours, and then approximately every 2 hours for an additional 8 hours. Insulin duration of action was defined as the number of hours from T(0) to the lowest blood glucose concentration and until blood glucose concentration returned to an interpolated value of 70% of basal blood glucose concentration (Glucose(b)).
RESULTS: Mean percent of insulin-induced blood glucose suppression was 49.9 +/- 17.1% (median, 46%; range, 29-78%). Insulin duration of action ranged from 4 to 10 hours. Blood glucose concentration increased initially and returned to Glucose(b) within 0.6-2.2 hours after T(0) in 5 dogs. This initial blood glucose surge then was followed by blood glucose suppression in all 5 dogs.
CONCLUSIONS AND CLINICAL IMPORTANCE: These results suggest that Humulin N administered SC twice daily is an effective mode of treatment for dogs with naturally occurring DM. Postprandial hyperglycemia is present in some well-regulated diabetic dogs treated with Humulin N.
Kathy
Am going to preface this before copying it as I think the word "analogue" used to describe Humulin N is confusing.
An analog or analogue insulin would be an insulin which doesn't exist in nature. Human insulin is an exact copy of the insulin a normal human body produces. Insulins Novolog, Humalog, Apidra, Lantus and Levemir never existed until science created them by altering human insulin to produce either more rapid or slower absorption.
Describing it as r-DNA or GE (Genetically Engineered) insulin would seem to be more apt; Humulin N has a LOT more in common with Novolin N and ReliOn Novolin N as well as the non North American brand names for isophane insulin than it does the analogs.
With the hope of avoiding confusion, I'll be omitting that word from this copy of the abstract; the link is above.
An investigation of the action of Neutral Protamine Hagedorn human insulin in dogs with naturally occurring diabetes mellitus.
Department of Clinical Studies, Matthew J. Ryan Veterinary Hospital, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA, USA.
Journal of Veterinary Internal Medicine 2009
BACKGROUND: Neutral Protamine Hagedorn human insulin (Humulin N) is commonly used for treatment of canine diabetes mellitus (DM). However, blood glucose and serum insulin concentrations in Humulin N-treated dogs with naturally occurring DM have not been reported.
OBJECTIVE: To investigate blood glucose and serum insulin concentrations in the clinical setting of client-owned Humulin N-treated dogs with naturally occurring, well-regulated DM.
ANIMALS: Ten client-owned dogs with naturally occurring, well-regulated DM.
METHODS: In this clinical study, blood glucose and serum insulin concentrations were measured when dogs received food and insulin (T(0)), at approximately every half hour for the next 2 hours, and then approximately every 2 hours for an additional 8 hours. Insulin duration of action was defined as the number of hours from T(0) to the lowest blood glucose concentration and until blood glucose concentration returned to an interpolated value of 70% of basal blood glucose concentration (Glucose(b)).
RESULTS: Mean percent of insulin-induced blood glucose suppression was 49.9 +/- 17.1% (median, 46%; range, 29-78%). Insulin duration of action ranged from 4 to 10 hours. Blood glucose concentration increased initially and returned to Glucose(b) within 0.6-2.2 hours after T(0) in 5 dogs. This initial blood glucose surge then was followed by blood glucose suppression in all 5 dogs.
CONCLUSIONS AND CLINICAL IMPORTANCE: These results suggest that Humulin N administered SC twice daily is an effective mode of treatment for dogs with naturally occurring DM. Postprandial hyperglycemia is present in some well-regulated diabetic dogs treated with Humulin N.
Kathy
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