Re: Soaphie
Kathy gave a good overview of all the reasons why Vetsulin/Caninsulin can result in some sharper drops in BG than NPH.
The combination of a lack of resistance because the insulin molecule is identical to a dog's natural insulin molecule and a more dilute solution gives a tendency at least for that to happen.
Our dog was a good example of one who processed zinc suspensions like Vetsulin and protamine suspensions like NPH very differently even though his zinc lente insulin was a U100 human-origin insulin -- Humulin L, which is no longer available. He got a pretty even supply of insulin from the NPH protamine version but took a long time to "break open" the zinc suspension of Humulin L (no longer available).
I'm just very glad we still have at least two choices of insulins. Every time an insulin type goes away, pets suffer. Humulin L was a really great insulin for a lot of dogs and Vetsulin/Caninsulin is not an exact substitute for it - a good thing for dogs who need something different, like Kathy's Lucky, but a bad thing for the dogs for whom Humulin L was the perfect insulin.
Kathy gave a good overview of all the reasons why Vetsulin/Caninsulin can result in some sharper drops in BG than NPH.
The combination of a lack of resistance because the insulin molecule is identical to a dog's natural insulin molecule and a more dilute solution gives a tendency at least for that to happen.
Our dog was a good example of one who processed zinc suspensions like Vetsulin and protamine suspensions like NPH very differently even though his zinc lente insulin was a U100 human-origin insulin -- Humulin L, which is no longer available. He got a pretty even supply of insulin from the NPH protamine version but took a long time to "break open" the zinc suspension of Humulin L (no longer available).
I'm just very glad we still have at least two choices of insulins. Every time an insulin type goes away, pets suffer. Humulin L was a really great insulin for a lot of dogs and Vetsulin/Caninsulin is not an exact substitute for it - a good thing for dogs who need something different, like Kathy's Lucky, but a bad thing for the dogs for whom Humulin L was the perfect insulin.
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